2008 Kaplan USMLE Step 1 Home Study Program-Brand New Volume by by Kaplan

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It is associated with a number of fetal defects, including growth retardation, abnormal brain development and CNS dysfunctions, cardiac abnormalities, facial dysmorphism, and joint defects. 2. Thalidomide is a sedative that was used widely by pregnant women from 1960 to 1962 until it was withdrawn from market. , total or partial absence of extremities), gastrointestinal defects, and cardiac defects. 3. Tetracycline exposure can result in teeth and skeletal abnormalities. 4. Isotretinoin exposure can result in ear, brain, and heart malformations.

Trisomy 13 (Patau syndrome) is characterized by mental retardation, malformed ears, a small head, congenital heart defects, renal anomalies, cleft lip and palate, deafness, and eye defects. 4. Klinefelter syndrome (most commonly )ffY) a. This syndrome is characterized by sterility, small testes, degeneration of seminiferous tubules, gynecomastia, tallness, and, sometimes, mental retardation. b. Within the nucleus, a darkly staining chromatin region, or Barr body, can be found. The presence of this sex chromatin is due to the random condensation and "shutdown" of all X chromosomes except one.

It is probably caused by a shorter length of the esophagus than normal. B. Mobile cecum and colon caused by to incomplete fusion of the ascending mesocolon with the peritoneum of the posterior abdominal wall. , volvulus) and obstruction of the ascending colon may result. It is treated by fixation of the ascending colon to the posterior abdominal wall. iiiBfical ,7 Pharyngeal Arches and Their Derivatives The pharyngeal (branchial) arches contribute to the formation of the lower head and neck. In the fourth and fifth weeks of development, these structures appear as condensations of mesenchymal tissue on the lateral walls of the foregut at the level of the pharynx.

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