Angiogenesis and Direct Myocardial Revascularization by Roger J. Laham, Donald S. Baim

By Roger J. Laham, Donald S. Baim

An interdisciplinary panel of pioneers and opinion leaders overview the elemental, preclinical, medical, and developmental pathways to new remedy options, corresponding to healing angiogenesis and myogenesis. The authors reap the benefits of new organic realizing, novel healing objectives, a number of to be had and well-studied healing recommendations, and the mandatory imaging thoughts to degree results. Their in-depth discussions conceal the id of recent healing goals and pathways, the research of transcriptional components, grasp change molecules, cell-based ways, chemokines, a greater knowing of the consequences of getting older, endothelial disorder, and hypercholesterolemia in line with angiogenic stimuli. Highlights contain exam of drug supply difficulties, results degree, stem remedy, high-risk interventions, improvement pathways, and destiny chances.

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Extra resources for Angiogenesis and Direct Myocardial Revascularization (Contemporary Cardiology)

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Because the process of blood vessel development is highly conserved over evolution, the use of alternate model systems has permitted easier access to studying blood vessel development. Two animal models that have been particularly useful for these studies are the developing zebrafish and chicken. Both have the advantages of allowing direct visualization of blood vessels. Two genes that have been identified in zebrafish and appear to be critical early regulators for initiating vascular development are cloche and spade tail (1).

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Adams RH, Diella F, Hennig S, Helmbacher F, Deutsch U, Klein R. The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell 2001;104:57–69. 45. Yamagishi H, Olson EN, Srivastava D. The basic helix-loop-helix transcription factor, dHAND, is required for vascular development. J Clin Invest 2000;105:261–270. 46. Shivdasani RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL.

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