Understanding Cardiac Electrophysiology: A Conceptually by Peter Spector

By Peter Spector

Within the fast-paced global of scientific education, scholars are usually inundated with the what of electrophysiology with no the why. This new textual content is designed to inform the tale of electrophysiology in order that the probably disparate myriad observations of scientific perform come into concentration as a cohesive and predictable complete.

  • Presents a special, conceptually-guided method of knowing the circulation of electric present throughout the middle, the impression of assorted affliction states and the optimistic impression of treatment
  • Reviews electrophysiologic ideas and the analytic instruments which, while mixed with an organization seize of EP mechanisms, enable the reader to imagine via any situation
  • Presents the maths worthwhile for the perform of cardiac electrophysiology in an obtainable and comprehensible manner
  • Contains accompanying movies, together with computing device simulations displaying the move of electric present in the course of the center, which aid clarify and visualise recommendations mentioned within the text
  • Includes necessary bankruptcy summaries and whole colour illustrations reduction comprehension

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Additional resources for Understanding Cardiac Electrophysiology: A Conceptually Guided Approach

Example text

A wave front that encroaches upon the relative refractory period will conduct, but with reduced conduction velocity (see Chapter 3); whereas a wave front that encounters the fully excitable gap will conduct at a normal velocity. Atrial fibrillation: a case study in reentry18 In the realm of reentry, fixed anatomic reentry is elegant physiology played out on the simplest possible playing field. Dynamic/functional reentry makes things a lot more interesting and as such is an excellent “classroom” for studying reentry.

16 18 Third-person omniscient (partial) refractory period occurs when some, but not all, sodium channels have recovered from inactivation. • K+ channels (largely) determine APD (which in turn determines refractory period). • IKr has rapid kinetics (no change in IKr with rate). • IKs has slow kinetics and incomplete opening with a single AP. Therefore at fast heart rates IKs “stacks,” causing shortened APD. ” Reverse use‐dependence confers a poor toxic/therapeutic ratio and thus can be pro‐arrhythmic (maximum effect at slow rates and minimum effect at rapid rates).

IK1), source current causes less depolarization. 4). What about the rate of depolarization? For any given depolarizing current the membrane will depolarize more slowly if: (1) the cell membrane area is large, (2) the cell has many gap junctions to many neighbors, and/or (3) the cell has a lot of open K+ channels. To get an intuitive feel for tissue conduction, imagine a line of buckets in a row. ). The force driving current from one cell to the next is the voltage gradient (here represented by the difference in water height between the buckets).

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